Intriguingly, the translocation t(6;22)(p21;q12) found in some undifferentiated sarcomas and neoplasms of skin and salivary glands directly fuses OCT4 to EWSR1. Among EWS-FLI1-repressed genes is also hsa-mir-145, a microRNA targeting OCT4 and other stem cell factors and feeding back on EWS-FLI1 expression [133]. This evidence concerns the gene FLI1 and sarcoma.