It is interesting to note that almost all attempts to experimentally restore the presumed “normal” expression pattern of these targets in ESFT cell lines (by ectopic reexpression of EWS-FLI1 repressed genes and knockdown of EWS-FLI1-activated genes) resulted in reduced tumor cell growth in vitro and/or reduced tumorigenicity in vivo and in several cases enhanced chemosensitivity (Table 3). The gene discussed is EWSR1; the disease is neoplasm.