RUNX1 and acute myeloid leukemia: RUNX1/AML1/CBFA2/PEBP2αB was discovered as a common chromosomal translocation target in chronic myelogenous and acute myeloid leukemias (reviewed in [31]), and its critical necessity for adult blood-cell production was discovered in RUNX1-null mice, which lacked definitive hematopoiesis [32, 33].