The discussion regarding the value of parafibromin as a discriminating marker took a new turn when a subsequent study showed excellent correlations between loss of parafibromin expression and HRPT2 gene mutations in which 21/22 sporadic adenomas were parafibromin positive whereas all 11 carcinomas were negative for parafibromin immunoreactivity using the 2H1 antibody [23]. This evidence concerns the gene CDC73 and carcinoma.