There were total 6 (2.7%) cases of nonTB-IRIS—2 patients with herpes zoster, 2 patients with cytomegalovirus infection (IgM positive and biopsy from gut lesion showing characteristic cytopathic effect), 1 patient with cryptococcal meningitis (India ink and cryptococcal antigen in CSF positive) and 1 patient with progressive multifocal leukoencephalopathy (confirmatory findings on MRI brain and culture for JC virus positive). Here, CD40LG is linked to progressive multifocal leukoencephalopathy.