However, when patients with any IRIS and ART-associated TB were compared with those who did not develop IRIS, statistically significant differences were found in increase in CD4 (136 (IQR 60–272) versus 53 (IQR 15–146) %; P = .023) and decrease in viral load (99.91 (IQR 99.8–99.93) versus 99.55 (IQR 98.76–99.9) %; P = .002). Here, CD4 is linked to tuberculosis.