Previous studies had found that depletion of CD4+CD25+ cells enhanced HCV-specific T cell response to HCV antigens; however, these studies also described enhanced T cell response to control antigens from Epstein-Bar Virus (EBV), Cytomegalovirus (CMV), and influenza indicating that the depletion of this subset of cells is not specific for HCV [4, 34]. The gene discussed is CD4; the disease is influenza.