Significant increases in the adipose tissue mRNA expressions of IL-6, TNF-α, TNFRSF1A, and CD68 were observed from cachectic to normal-weight, overweight, and obese COPD patients (ANOVA for trend, P < .001; P = .005; P = .011, P = .011, resp). This evidence concerns the gene CD68 and chronic obstructive pulmonary disease.