In mouse models, efficacy of DNA vaccines encoding for all known melanoma-associated antigens was reported including gp100 (melanocyte protein 17/Pmel-17), GRP (gastrin-releasing peptide) [102], MAGE-1 (melanoma-associated antigen) [103], MART-1, MUC-18/MCAM [104], TRP-1 (tyrosinase-related protein-1/gp75), TRP-2, or tyrosinase. The gene discussed is TYR; the disease is melanoma.