Variants in other regions such as the human leukocyte antigen (HLA) locus, mitochondrial genome, interleukin 8 (IL8), apolipoprotein E (ApoE), and factor I (FI), may alter the risk of AMD, but additional studies are needed due to inconsistent or absent replication in independent study groups [14-17]. Here, APOE is linked to age-related macular degeneration.