Several studies in the past have shown independent parameters like splenomegaly,[10, 11, 17, 18, 22] ascites,[12, 18] spider naevi,[13] Child’s grade,[15] platelet count,[11–18, 20, 22] prothrombin time/activity,[13, 16] portal vein diameter,[16] platelet count/ spleen diameter ratio,[19, 21] serum albumin,[20] and serum bilirubin[20] as significant predictors for the presence of esophageal varices. The gene discussed is ALB; the disease is Splenomegaly.