DISC1 and schizophrenia: In a similar vein, the recent demonstration of at least fifty different DISC1 transcripts including an abundance that are specific to foetal development and some for which expression is altered in the hippocampus of those suffering from schizophrenia or carrying DISC1 schizophrenia-risk alleles (Nakata et al., 2009), raised a whole new series of questions about how DISC1 expression is regulated, and with what effect on neurodevelopment and signalling.