The major ceramide species (in descending order) and their fecal excretion rates (nmol/mouse/day) in HF and HFPL mice were: Cer 16:0, 11.1 ± 1.0 vs 41.6 ± 3.4, P < 0.001; Cer 18:1, 7.4 ± 0.9 vs 31.5 ± 2.7, P < 0.001; Cer 18:0, 4.2 ± 0.4 vs 20.4 ± 1.7, P < 0.001; Cer 22:0, 2.4 ± 0.2 vs 26.3 ± 2.6, P < 0.001; Cer 24:0, 1.9 ± 0.2 vs 23.2 ± 2.4, P < 0.001. The gene discussed is CBLN1; the disease is hydrops fetalis.