T-cell autoreactivity in lupus is thought to be due in part to the overexpression of adhesion molecule lymphocyte function-associated antigen 1 (LFA-1, composed of cluster of differentiation (CD) 11a and CD18 subunits) [4,5], and of CD70 (TNFSF7), which induces B cells to over-produce autoantibodies [6,7]. Here, ITGAL is linked to systemic lupus erythematosus.