CD11a and CD70 promoter H3K9 tri-methylation levels were significantly higher in RFX1-overexpressing SLE CD4+ T cells compared to control-transfected SLE CD4+ T cells (Figure 5b), and this change correlated with a decrease in the expression of CD11a and CD70 mRNA (Figure 5c). This evidence concerns the gene ITGAL and systemic lupus erythematosus.