The average numbers of HCCLM6 cells transfected with c-Myb siRNA migrating toward the conditioned medium or invading through the Matrigel were significantly fewer than those transfected with scramble siRNA (Migration assay: 17.60 ± 4.04 vs 33.60 ± 4.67, P < 0.05; Invasion assay: 8.00 ± 2.55 vs 18.8 ± 4.15, P < 0.05, Figure 4), This result showed that the capability of migration and invasion in HCCLM6 cells was significantly decreased after inhibition of c-Myb, suggesting that c-Myb is an important contributor to the migration and invasion of HCC cells. The gene discussed is MYB; the disease is hepatocellular carcinoma.