Eag channels have also been shown to have increased expression in various cancer cell lines namely IGR1, IPC298, and IGR39 (melanoma) [42], SH-SY5Y (neuroblastoma) [43] and MCF-7 (breast cancer) cell lines and various cancers such as gliomas [44], cervical cancers [45], colon carcinoma [46], gastric cancers [47] and sarcomas [48]. This evidence concerns the gene KCNH1 and melanoma.