However PKC ζ demonstrated a significant decrease in the expression in coronary vessels of Gα11 knockout mice after 8 weeks of diabetes (PKC ζ [densitometric Units] C: 253.11 ± ± 38.45; DM: 132.16 ± ± 33.8; p = 0.042) (Figure 3C vs Figure 3D) in contrast to wildtype animals. Here, GNA11 is linked to diabetes mellitus.