LEF1 is a transcription factor in the Wnt pathway that is important for cell fate determination and cell differentiation in several tissues, including multipotent stem cell lineages in the skin [53] and is also important in the bone marrow, where LEF1 expression is greatly reduced in congenital neutropenia-arrested promyelocytes [54,55]. The gene discussed is LEF1; the disease is Decreased total neutrophil count.