Cytokine namely TNF-α has been implicated in insulin resistance.[5] TNF-α stimulates the endothelial production of adhesion molecules such as E-selectin and vascular cell adhesion molecule-1 (VCAM-1).[6] E-selectin and VCAM-1 accelerate the atherosclerosis and vascular complications in diabetes.[7] In this view, development of a drug which modulates the cytokine TNF-α in type 2 diabetes would be a novel approach in early intervention of the disease. This evidence concerns the gene TNF and diabetes mellitus.