PSMA expression was specifically detected on the neovasculature of many other prostates not related tumors, suggesting the possibility that PSMA may also functionally contribute to angiogenesis of primary and metastatic cancers [26,27].Therefore, it has been suggested that PSMA may be utilized both as a marker and as a therapeutic target [26,6]. This evidence concerns the gene FOLH1 and metastatic malignant neoplasm.