NPPB and hydrops fetalis: Therefore, we investigated the predictive value of galectin-3 in HF due to HFREF or HFPEF and compared this to an established biomarker, NT-pro-brain natriuretic peptide (NT-proBNP), and to several cytokines that have been associated with HF and that have been pathophysiologically related to galectin-3, including IL-6 and hsCRP.