LGALS3 and hydrops fetalis: The pathophysiological role for galectin-3 in development and progression of HF has been supported by several other experimental models of HF, like interferon-γ-induced murine chronic active myocarditis and cardiomyopathy (14), rat streptozotocin-induced diabetic cardiomyopathy (15), and angiotensin II-induced hypertension in rats (16).