Additionally, there were two patients with chronic active hepatitis in the group A, as well as one patient with rheumatoid arthritis, one patient with a collagen disease and one patient with Dühring's disease in the group B. In two patients secondary adrenal insufficiency appeared after three and 18 years of AD duration with loss of hyperpigmentation and a decrease of ACTH concentration from 165.6 to 4.0 and from 74 to 2.2 pmol/L, respectively. The gene discussed is POMC; the disease is Alzheimer disease.