In human, GVHD proceeded by an allogenic stem cell graft and immunosuppressive prophylaxis, the analysis of biopsies from intestinal GVHD showed a decrease of CD4+-T cells infiltrate when recipient carried NOD2 GVHD associated variants whereas the donor NOD2 status had no significant impact on the CD4+ cell infiltrates [108]. This evidence concerns the gene CD4 and graft versus host disease.