Recently, our group addressed the immunohistopathology of skin and gut GvHD in relation to absence and presence of NOD2 SNPs: In both tissues, skin and gut, recipient NOD2 SNPs had no impact on the extent of apoptosis as the hallmark of GvHD nor on the CD8 and macrophage infiltrate in the biopsies. The gene discussed is CD8A; the disease is graft versus host disease.