Er et al. [15] found a significant correlation between tHcy level and ocular BD (18.25 ± 4.2 versus 13.53 ± 3.34 μmol/L; P = .001); in addition, ocular BD had significantly higher serum endotheline-1 concentrations when compared with nonocular disease (19.17 ± 5.02 versus 15.62 ± 2.48 μmol/L; P = .003). The gene discussed is EDN1; the disease is Behcet disease.