An increase in type 3 collagen may result in reduced collagen fibril assembly in the abdominal wall, leading to development of hernia.[1] In another study, it was stated that the ratio of type 1 / type 3 collagen was markedly reduced in the hernial sac of patients with inguinal hernia.[2] In recurrent hernias, these patients were found to have an increase in both procollagen type 3 mRNA and subsequent type 3 collagen synthesis as well as increase in matrix metalloproteinases 1 and 13.[3] This strongly suggests that recurrent inguinal hernias could be a disease of the collagen matrix. This evidence concerns the gene SGCG and Inguinal hernia.