P2RX7 and renal fibrosis: BBG is more specific for just P2X7 [19], [20], [21], and because of the awareness of the importance of P2X7 in processes such as cytokine release, inflammatory and neuropathic pain and renal fibrosis [21], there has been a major effort to develop more specific and potent inhibitors [19], such as AZ11645373 [22].