In our study, we showed that EHEC ΔnleC but not EPEC ΔnleC has statistically significant relief on host IL-8 response; this discrepancy between these two close-related pathogen may due to differences in their infection efficiency and amount of other translocated anti-inflammatory effectors, such as NleE or NleB. The gene discussed is CXCL8; the disease is infection.