Some examples of HIV-interacting gene that responded to stimulation with LPS exclusively in chimpanzees include ITGB2(CD18) and ITGAM(CD11b), which are the two members of the complement receptor 3 (CR3) that have been shown to play a key role in the infection of dendritic cells by C3-opsonized HIV [49], [50] and the viral transfer to CD4 T cells [50]. Here, CD4 is linked to infection.