MTHFR and Stroke: Evidence of MTHFR C677T polymorphism may slightly predispose to young adults to the development of stroke on German population.[24] A study investigated that MTHFR 677CT polymorphism, though associated with homocysteine levels, confers no significant risk of CAD in the Pakistani population.[25] Limited data are available for other Asian populations, especially Indians.[26–28] Nair et al,[26] reported that heterozygosity for thermolabile MTHFR mutation was associated with hyperhomocysteinemia, which could be a risk factor for CAD in the Indian population.