INS and obesity due to melanocortin 4 receptor deficiency: The risk of progressing to diabetes depends on the degree of insulin resistance and deficiency of insulin secretion as well as other diabetes risk factors, such as age, family history, overweight/obesity, or history of gestational diabetes.[31, 32] Previous studies have shown that visceral fat in young healthy individuals and older adults is associated with increased cardiovascular risk factors.[33] This study confirms this association.