V$EVI1 - V$EGRF and - V$LEFF in Table 5 indicate conservation in the promoters of genes that co-vary with Nnat. There are important transcription factors in these families, for example Egr2 and Tcf7l2, which are implicated in stress responses and T2D; E2f which is concerned with adipogenesis and Evi1, which activates Stat3, a transcription factor concerned with leptin signalling in the hypothalamus. This evidence concerns the gene STAT3 and type 2 diabetes mellitus.