Other important TFs with conserved binding sites in the Nnat promoter and which are highly expressed in WAT include several genes which have crucial roles in the control of: adipogenesis (Klf15, Irf1, Creb1, Egr2, Gata3); lipogenesis (Mlxipl, Srebp1c); inflammation (Jun, Stat3); insulin signalling and diabetes susceptibility (Foxo1, Tcf7l2). The gene discussed is FOXO1; the disease is diabetes mellitus.