CD4 and synovial sarcoma: Although these earlier studies have implicated both TH1 and TH2 cell-associated functions in the development and onset of clinical SS, recent identification of the CD4+ TH17 memory cells within the lymphocytic focus (LF) of lacrimal and salivary glands of SSs C57BL/6.NOD-Aec1Aec2 mice, as well as minor salivary glands of human SS patients, greatly expands the potential complexity in deciphering the autoimmune response underlying SS [8,9].