This group of loci includes Adamts5 (a disintegrin-like metallopeptidase with thrombospondin type 1 motif, 5; involved in osteoarthritis, [69]), Clec2b (C-type lectin domain family 1 involved in platelet activation and aggregation, [70]), Ctsc (Cathepsin C required for the activation of Granzymes A and B, [71]), Ldlr (Low density lipoprotein receptor involved in cholesterol homeostasis, induced by inflammation, [72]), and Samd9l (Sterile alpha motif domain containing 9-like involved in cytokine signaling [73]). The gene discussed is VLDLR; the disease is osteoarthritis.