The C-reactive protein levels in BAV patients have not been found to correlate with aortic diameter, but have shown an association with advanced calcific valve disease.69 The plasma levels of C-reactive protein have been found to be higher in patients with BAVs or degenerative stenotic tricuspid aortic valves than in normal controls and patients with pure aortic regurgitation.70 In the presence of aortic dilation or infective endocarditis, patients may have anemia with an elevated erythrocyte sedimentation rate.59 This evidence concerns the gene CRP and infective endocarditis.