Schizophrenia, a heterogeneous construct, is likely to be influenced by various balancing advantages–creativity being one of them.[6] While the recently reported link between neuregulin 1 and creativity[2] offers important evidence in support of this, other works (as summarized above) strengthen the evolutionary significance of neuregulin 1 gene not only for schizophrenia, perhaps, but also for origins of Homo sapiens. This evidence concerns the gene NRG1 and schizophrenia.