The link between creativity and psychosis has derived more support from a recent demonstration of a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene, which is linked with schizophrenia,[1] associated with creativity in people with high intellectual and academic performance.[2] In this letter, we summarize further comparative genomic analyses supporting positive selection of neuregulin 1 gene that further adds to its significance in the context of creativity and psychosis from the perspectives of human evolution. Here, NRG1 is linked to psychotic disorder.