Although the initial definition of amyloid was extracellular deposition of proteinaceous fibrillar material, the use of the term has changed as more evidence exists on the presence of intracellular aggregates of i.e. Aβ in AD [38], [39], [40] and islet amyloid polypeptide-derived amyloid in type II diabetes [41]. This evidence concerns the gene IAPP and type 2 diabetes mellitus.