TTR and amyloidosis: In a previous work, we have generated a transgenic model for TTR-associated amyloidosis in the fly Drosophila melanogaster by overexpressing either normal TTR (TTRwt), the clinically relevant mutant TTRL55P, or the highly destabilized engineered mutant TTR-A (TTRV14N/V16E; [20]), all in secreted form and thus detectable in hemolymph [21].