Lack of anti-apoptotic GRP78 induction could contribute to cell death in maintaining the three transducers of ER stress (PERK, IRE1α and ATF6) under an activated status and down-regulation of GRP78 is known to sensitize tumor cells to apoptosis induced by current anti-cancer therapies [52], [53], [54]. This evidence concerns the gene EIF2AK3 and cancer.