IRAK3 and neoplasm: Expression profiling studies carried out in this V12RAS-induced melanoma model reveal extensive up-regulation of pro-inflammatory genes, for example, ifn1, il8, and irak3, in the tumor tissue compared with control tissue (P. Walker, M. Jones, S. He, C. Michailidou, N. Haud, et al., unpublished data), suggesting that inflammation may play a role during V12RAS-induced tumorigenesis.