In contrast to the identification of SHP and PR in the tumor samples as key predictors, the normal lung epithelium profile classification tree structures revealed two other NRs, NGFIB3 (nerve growth factor induced gene B3, also known as NR4A1) and mineralocorticoid receptor (MR, also known as NR3C2) to be single gene predictors for survival and disease recurrence. This evidence concerns the gene NR4A1 and neoplasm.