After stratification for duration of latent infection, the differences from active TB in the single cytokine-secreting ESAT-6/CFP-10-specific functional T cell subsets remained significant for the remotely-infected (p = 0.03, p = 0.07 and p = 0.03 for IFN-γ-only-secreting, IFN-γ/IL-2-secreting and IL-2-only-secreting T cells, respectively) but not the recently-infected subgroup (p = 0.15, p = 0.16, p = 0.18, respectively). The gene discussed is IFNG; the disease is disease arising from reactivation of latent virus.