Compared to active TB patients, the LTBI donors had a significantly lower proportion of ESAT-6/CFP-10-specific IFN-γ-only secreting T cells and significantly higher proportions of ESAT-6/CFP-10-specific dual IFN-γ/IL-2-secreting and IL-2-only secreting T cells, confirming our hypothesis. This evidence concerns the gene IFNG and tuberculosis.