HDAC9 and non-small cell lung carcinoma: Figure 2C illustrates that LBH589 treatment caused histone H3 phosphorylation accompanied by increased histone acetylation and PARP cleavage, indicating that HDACi treatment causes NSCLC cells to enter mitosis and undergo cell death. To determine whether cell growth and viability changes observed after LBH589 treatment are a generalized effect of HDAC inhibition, we also used another pan-HDACi, scriptaid (1 μM), which produced biochemical changes indistinguishable from those presented above using LBH589 (Figure 3).