Up-regulation of HIF-1α and down-regulation of VEGFR1 is reported to be characteristic to infantile hemangioma while down-regulation of VEGFR1 is also seen in angiosarcoma, and such abnormal expression of angiogenic factors are thought to play some role in their pathogenesis [21], [24], [25]. Here, HIF1A is linked to capillary hemangioma.