Interestingly, in mice model it was shown that among HIV proteins, Nef harbours a major disease determinant and Nef expressing in CD4+Tcells and macrophage/dendrite lineages develop severe AIDS-like pathogenesis: failure to thrive/weight loss, diarrhoea, wasting, premature death, thymus atrophy, loss of CD4+ T cell, interstitial pneumonitis, and tubulo-interstitial nephritis. Here, CD4 is linked to Interstitial pneumonitis.