TGFB1 and neoplasm: On the other hand, additional studies are necessary to determine whether IL-13 might stimulate potentially beneficial immunosuppressive activity by inducing alternatively activated (M2) macrophages with anti-inflammatory properties [52]; [53] or by inducing TGFβ production from immature myeloid cells, as was described for responses of non-invariant NKT cells in tumor bearing mice [54]; [55].