INS and early-onset autosomal dominant Alzheimer disease: KEGG pathway analysis of CMP-regulated genes revealed significant population of functional signaling pathways including: protein synthesis (Ribosome); neurophysiology (Alzheimer's disease, neurodegenerative disorders, long-term depression); energy regulation (urea cycle/metabolism of amino acids); metabolic signaling (insulin/mTOR signaling pathways) and pathways linked to cellular architecture (focal adhesion) (Table 2).