But since the hypercholesterolemia is also recognized as a causative factor in the development of atherosclerosis and hypertension, treatment with a beta-adrenergic blocking agent Metoprolol which is known to reduce the chest pain and lowering the high blood pressure also have antiatherosclerotic effects and Ramipril ACE (angiotensin converting enzyme) will always be a beneficial point for the patients by controlling hypertension, angina associated with dyslipidemia and metabolic syndrome. The gene discussed is ACE; the disease is blood pressure trait.