In this group of MMR-proficient colorectal cancer, only 7 patients had tumors with CD8+/TIA-1- TILs In univariable analysis, survival time differences for patients with CD8+/TIA-1+ TILs were significantly higher compared to patients with absence of CD8+ TILs (p<0.0001). The gene discussed is CD8A; the disease is colorectal cancer.