SSPN and famililal cerebral cavernous malformations: Cerebral cavernous malformation 2 (CCM2) [47], insulin-like growth factor binding protein 3 (IGFBP3) [48], sarcospan (Kras oncogene-associated gene); (SSPN) [49], and transforming growth factor, beta 2 (TGFB2) [50] were selected and screened as candidates under these criteria.