c-kit positive (c-kitpos) cardiac stem cells (CSCs) are the only adult derived cardiac stem/progenitor cells shown to exhibit all the characteristics of bona fide stem cells, being clonogenic, self-renewing, multipotent and having substantial regenerative potential in an in vivo animal myocardial infarction (MI) regeneration assay [5]. The gene discussed is KIT; the disease is myocardial infarction.