HIF1A and Familial prostate cancer: As a result of HIF-1α downregulation, zinc abolished the hypoxia-induced HIF-1α recruitment onto its binding sites in the VEGF promoter in C38 cells and in basal “constitutively hypoxic” condition in C27 cells (Figure 2C); similarly, zinc inhibited the hypoxia-induced HIF-1α recruitment onto hTERT promoter (not shown) which has been previously shown to be regulated by HIFs-α in the prostate cancer model [9].