Since translational research within the last few years failed to demonstrate an important role for TNF-α in inducing insulin resistance in humans, in the present study we aimed to examine if IL-6 might be of clinical relevance in this context by measuring insulin sensitivity, adipokine serum levels and lipid parameters in patients with immunological disease before and at 1 and 3 months of Tocilizumab therapy. The gene discussed is TNF; the disease is Insulin resistance.