INS and type 2 diabetes mellitus: From a pathophysiological point of view, the results obtained by Ogata et al. [44] and the data presented here give promising evidence for future studies using Tocilizumab as a tool to examine the effect of IL-6 on insulin sensitivity in human individuals not suffering from an immunological disease to further clarify the role of IL-6 in the pathogenesis of type 2 diabetes.